Displacement of Bim by Bmf and Puma rather than increase in Bim level mediates paclitaxel-induced apoptosis in breast cancer cells

Taxanes exert their antitumor effect via stabilizing microtubule dynamics and initiating G2/M arrest in cancer cells followed by apoptotic cell death. However, the signaling pathways that connect paclitaxel-induced microtubule perturbation to mitochondrial outer membrane permeabilization (MOMP) and...

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Detalles Bibliográficos
Autores principales: Kutuk, Ozgur, Letai, Anthony
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914832/
https://www.ncbi.nlm.nih.gov/pubmed/20431602
http://dx.doi.org/10.1038/cdd.2010.41

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914832/
https://www.ncbi.nlm.nih.gov/pubmed/20431602
http://dx.doi.org/10.1038/cdd.2010.41

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