Cargando…

Foot-and-Mouth Disease Virus 2C Is a Hexameric AAA+ Protein with a Coordinated ATP Hydrolysis Mechanism

Foot-and-mouth disease virus (FMDV), a positive sense, single-stranded RNA virus, causes a highly contagious disease in cloven-hoofed livestock. Like other picornaviruses, FMDV has a conserved 2C protein assigned to the superfamily 3 helicases a group of AAA+ ATPases that has a predicted N-terminal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sweeney, Trevor R., Cisnetto, Valentina, Bose, Daniel, Bailey, Matthew, Wilson, Jon R., Zhang, Xiaodong, Belsham, Graham J., Curry, Stephen
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915670/ https://www.ncbi.nlm.nih.gov/pubmed/20507978 http://dx.doi.org/10.1074/jbc.M110.129940

Ejemplares similares

The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II
por: Bloemink, Marieke J., et al.
Publicado: (2016)

The Allosteric Role of the AAA(+) Domain of ChlD Protein from the Magnesium Chelatase of Synechocystis Species PCC 6803
por: Adams, Nathan B. P., et al.
Publicado: (2013)

Insights into the Cnx1E catalyzed MPT-AMP hydrolysis
por: Hercher, Thomas W., et al.
Publicado: (2020)

trans-Acting Arginine Residues in the AAA+ Chaperone ClpB Allosterically Regulate the Activity through Inter- and Intradomain Communication
por: Zeymer, Cathleen, et al.
Publicado: (2014)

ATP and AMP Mutually Influence Their Interaction with the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) at Separate Binding Sites
por: Randak, Christoph O., et al.
Publicado: (2013)

ATPase Mechanism of the 5′-3′ DNA Helicase, RecD2: EVIDENCE FOR A PRE-HYDROLYSIS CONFORMATION CHANGE
por: Toseland, Christopher P., et al.
Publicado: (2013)

Structural analysis of group II chitinase (ChtII) catalysis completes the puzzle of chitin hydrolysis in insects
por: Chen, Wei, et al.
Publicado: (2018)

Demonstration of Phosphoryl Group Transfer Indicates That the ATP-binding Cassette (ABC) Transporter Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Exhibits Adenylate Kinase Activity
por: Randak, Christoph O., et al.
Publicado: (2012)

The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader
por: Puri, Neha, et al.
Publicado: (2021)

Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia
por: Dong, Qian, et al.
Publicado: (2015)

Computer Simulation of Assembly and Co-operativity of Hexameric AAA ATPases
por: Le, Doan Tuong-Van, et al.
Publicado: (2013)

Hexameric assembly of the AAA+ protein McrB is necessary for GTPase activity
por: Nirwan, Neha, et al.
Publicado: (2019)

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION
por: Benson, Matthew A., et al.
Publicado: (2013)

The role of conserved residues in Fdc decarboxylase in prenylated flavin mononucleotide oxidative maturation, cofactor isomerization, and catalysis
por: Bailey, Samuel S., et al.
Publicado: (2018)

Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody
por: Kenniston, Jon A., et al.
Publicado: (2014)

Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX
por: Stinson, Benjamin M., et al.
Publicado: (2015)

Dissecting the Catalytic Mechanism of Trypanosoma brucei Trypanothione Synthetase by Kinetic Analysis and Computational Modeling
por: Leroux, Alejandro E., et al.
Publicado: (2013)

Analysis of Nucleotide Binding to P97 Reveals the Properties of a Tandem AAA Hexameric ATPase
por: Briggs, Louise C., et al.
Publicado: (2008)

A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage
por: Pfaffen, Stephanie, et al.
Publicado: (2015)

Estradiol and progesterone affect enzymes but not glucose consumption in a mink uterine cell line (GMMe)
por: Holmlund, Hayden, et al.
Publicado: (2020)

Self-assembly Is Prerequisite for Catalysis of Fe(II) Oxidation by Catalytically Active Subunits of Ferritin
por: Ebrahimi, Kourosh Honarmand, et al.
Publicado: (2015)

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism
por: Wilson, Claire H., et al.
Publicado: (2013)

Regulation of Response Regulator Autophosphorylation through Interdomain Contacts
por: Barbieri, Christopher M., et al.
Publicado: (2010)

A Conformational Sampling Model for Radical Catalysis in Pyridoxal Phosphate- and Cobalamin-dependent Enzymes
por: Menon, Binuraj R. K., et al.
Publicado: (2014)

Novosphingobium aromaticivorans uses a Nu-class glutathione S-transferase as a glutathione lyase in breaking the β-aryl ether bond of lignin
por: Kontur, Wayne S., et al.
Publicado: (2018)

Stereochemical Features of Glutathione-dependent Enzymes in the Sphingobium sp. Strain SYK-6 β-Aryl Etherase Pathway
por: Gall, Daniel L., et al.
Publicado: (2014)

Scaffold stability and P14′ residue steric hindrance in the differential inhibition of FXIIa by Aedes aegypti trypsin inhibitor versus Infestin-4
por: Walvekar, Varsha Ashok, et al.
Publicado: (2022)

Nitro-fatty acids as activators of hSIRT6 deacetylase activity
por: Carreño, Mara, et al.
Publicado: (2021)

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases
por: Malcolm, Tess R., et al.
Publicado: (2021)

The Recruitment of AMP-activated Protein Kinase to Glycogen Is Regulated by Autophosphorylation
por: Oligschlaeger, Yvonne, et al.
Publicado: (2015)

Sequential and differential interaction of assembly factors during nitrogenase MoFe protein maturation
por: Jimenez-Vicente, Emilio, et al.
Publicado: (2018)

Snapshots during the catalytic cycle of a histidine acid phytase reveal an induced-fit structural mechanism
por: Acquistapace, Isabella M., et al.
Publicado: (2020)

The Naphthoquinone Diospyrin Is an Inhibitor of DNA Gyrase with a Novel Mechanism of Action
por: Karkare, Shantanu, et al.
Publicado: (2013)

Heme ligation and redox chemistry in two bacterial thiosulfate dehydrogenase (TsdA) enzymes
por: Jenner, Leon P., et al.
Publicado: (2019)

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites
por: Artz, Jennifer D., et al.
Publicado: (2011)

Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis
por: Seeliger, Jessica C., et al.
Publicado: (2012)

A heterodimeric glutathione S-transferase that stereospecifically breaks lignin's β(R)-aryl ether bond reveals the diversity of bacterial β-etherases
por: Kontur, Wayne S., et al.
Publicado: (2019)

Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin
por: Helmich, Kate E., et al.
Publicado: (2016)

Structural Characterization and Ligand/Inhibitor Identification Provide Functional Insights into the Mycobacterium tuberculosis Cytochrome P450 CYP126A1
por: Chenge, Jude T., et al.
Publicado: (2017)

Investigating the reaction and substrate preference of indole-3-acetaldehyde dehydrogenase from the plant pathogen Pseudomonas syringae PtoDC3000
por: Zhang, Kaleena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lbuhtgqfjae1dahs3mb51mebsi