“One Ring to Bind Them All”—Part II: Identification of Promising G-Quadruplex Ligands by Screening of Cyclophane-Type Macrocycles

A collection of 26 polyammonium cyclophane-type macrocycles with a large structural diversity has been screened for G-quadruplex recognition. A two-step selection procedure based on the FRET-melting assay was carried out enabling identification of macrocycles of high affinity (ΔT (1/2) up to 30°C) a...

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Detalles Bibliográficos
Autores principales: Granzhan, Anton, Monchaud, David, Saettel, Nicolas, Guédin, Aurore, Mergny, Jean-Louis, Teulade-Fichou, Marie-Paule
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915812/
https://www.ncbi.nlm.nih.gov/pubmed/20725622
http://dx.doi.org/10.4061/2010/460561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915812/
https://www.ncbi.nlm.nih.gov/pubmed/20725622
http://dx.doi.org/10.4061/2010/460561

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