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Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

Studies of T cell responses to tumors have focused on the draining lymph node (LN) as the site of activation. We examined the tumor mass as a potential site of activation after adoptive transfer of naive tumor-specific CD8 T cells. Activated CD8 T cells were present in tumors within 24 h of adoptive...

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Detalles Bibliográficos
Autores principales: Thompson, Elizabeth D., Enriquez, Hilda L., Fu, Yang-Xin, Engelhard, Victor H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916130/
https://www.ncbi.nlm.nih.gov/pubmed/20660615
http://dx.doi.org/10.1084/jem.20092454