Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice

Gene knockout and knockdown methods were used to examine essentiality of pteridine reductase (PTR1) in pterin metabolism in the African trypanosome. Attempts to generate PTR1 null mutants in bloodstream form Trypanosoma brucei proved unsuccessful; despite integration of drug selectable markers at th...

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Detalles Bibliográficos
Autores principales: Sienkiewicz, Natasha, Ong, Han B, Fairlamb, Alan H
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916222/
https://www.ncbi.nlm.nih.gov/pubmed/20545846
http://dx.doi.org/10.1111/j.1365-2958.2010.07236.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916222/
https://www.ncbi.nlm.nih.gov/pubmed/20545846
http://dx.doi.org/10.1111/j.1365-2958.2010.07236.x

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