Cargando…
Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice
Gene knockout and knockdown methods were used to examine essentiality of pteridine reductase (PTR1) in pterin metabolism in the African trypanosome. Attempts to generate PTR1 null mutants in bloodstream form Trypanosoma brucei proved unsuccessful; despite integration of drug selectable markers at th...
| Autores principales: | , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2010
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916222/ https://www.ncbi.nlm.nih.gov/pubmed/20545846 http://dx.doi.org/10.1111/j.1365-2958.2010.07236.x |