Maternal high-fat diet interacts with embryonic Cited2 genotype to reduce Pitx2c expression and enhance penetrance of left–right patterning defects

Deficiency of the transcription factor Cited2 in mice results in cardiac malformation, adrenal agenesis, neural tube, placental defects and partially penetrant cardiopulmonary laterality defects resulting from an abnormal Nodal->Pitx2c pathway. Here we show that a maternal high-fat diet more than...

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Detalles Bibliográficos
Autores principales: Bentham, Jamie, Michell, Anna C., Lockstone, Helen, Andrew, Daniel, Schneider, Jürgen E., Brown, Nigel A., Bhattacharya, Shoumo
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916708/
https://www.ncbi.nlm.nih.gov/pubmed/20566713
http://dx.doi.org/10.1093/hmg/ddq251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916708/
https://www.ncbi.nlm.nih.gov/pubmed/20566713
http://dx.doi.org/10.1093/hmg/ddq251

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