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Lysine120 Interactions with p53 Response Elements can Allosterically Direct p53 Organization

p53 can serve as a paradigm in studies aiming to figure out how allosteric perturbations in transcription factors (TFs) triggered by small changes in DNA response element (RE) sequences, can spell selectivity in co-factor recruitment. p53-REs are 20-base pair (bp) DNA segments specifying diverse fun...

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Detalles Bibliográficos
Autores principales: Pan, Yongping, Nussinov, Ruth
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2916859/
https://www.ncbi.nlm.nih.gov/pubmed/20700496
http://dx.doi.org/10.1371/journal.pcbi.1000878