Cargando…

The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome

Viomycin and capreomycin belong to the tuberactinomycin family of antibiotics, which are among the most effective antibiotics against multidrug-resistant tuberculosis. Here we present two crystal structures of the 70S ribosome complexed with three tRNAs and bound to either viomycin or capreomycin at...

Descripción completa

Detalles Bibliográficos
Autores principales: Stanley, Robin E., Blaha, Gregor, Grodzicki, Robert L., Strickler, Michael D., Steitz, Thomas A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917106/
https://www.ncbi.nlm.nih.gov/pubmed/20154709
http://dx.doi.org/10.1038/nsmb.1755