Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide

[Image: see text] We have previously shown that a 28-amino acid peptide derived from the BRC4 motif of BRCA2 tumor suppressor inhibits selectively human RAD51 recombinase (HsRad51). With the aim of designing better inhibitors for cancer treatment, we combined an in silico docking approach with in vi...

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Detalles Bibliográficos
Autores principales: Nomme, Julian, Renodon-Cornière, Axelle, Asanomi, Yuya, Sakaguchi, Kazuyasu, Stasiak, Alicja Z., Stasiak, Andrzej, Norden, Bengt, Tran, Vinh, Takahashi, Masayuki
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2010
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917172/
https://www.ncbi.nlm.nih.gov/pubmed/20684611
http://dx.doi.org/10.1021/jm1002974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917172/
https://www.ncbi.nlm.nih.gov/pubmed/20684611
http://dx.doi.org/10.1021/jm1002974

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