Structure of Staphylococcus aureus adenylo­succinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery

The medium-resolution structure of adenylosuccinate lyase (PurB) from the bacterial pathogen Staphylococcus aureus in complex with AMP is presented. Oxalate, which is likely to be an artifact of crystallization, has been modelled in the active site and occupies a position close to that where succina...

Descripción completa

Detalles Bibliográficos
Autores principales: Fyfe, Paul K., Dawson, Alice, Hutchison, Marie-Theres, Cameron, Scott, Hunter, William N.
Formato: Texto
Lenguaje:English
Publicado: International Union of Crystallography 2010
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917274/
https://www.ncbi.nlm.nih.gov/pubmed/20693687
http://dx.doi.org/10.1107/S0907444910020081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917274/
https://www.ncbi.nlm.nih.gov/pubmed/20693687
http://dx.doi.org/10.1107/S0907444910020081

Ejemplares similares