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Promoting crystallization of antibody–antigen complexes via microseed matrix screening
The application of microseed matrix screening to the crystallization of antibody–antigen complexes is described for a set of antibodies that include mouse anti-IL-13 antibody C836, its humanized version H2L6 and an affinity-matured variant of H2L6, M1295. The Fab fragments of these antibodies were c...
Autores principales: | Obmolova, Galina, Malia, Thomas J., Teplyakov, Alexey, Sweet, Raymond, Gilliland, Gary L. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917276/ https://www.ncbi.nlm.nih.gov/pubmed/20693692 http://dx.doi.org/10.1107/S0907444910026041 |
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