Cell type-specific anti-cancer properties of valproic acid: independent effects on HDAC activity and Erk1/2 phosphorylation

BACKGROUND: The anti-epileptic drug valproic acid (VPA) has attracted attention as an anti-cancer agent. METHODS: The present study investigated effects of VPA exposure on histone deacetylase (HDAC) inhibition, cell growth, cell speed, and the degree of Erk1/2 phosphorylation in 10 cell lines (BT4C,...

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Detalles Bibliográficos
Autores principales: Gotfryd, Kamil, Skladchikova, Galina, Lepekhin, Eugene A, Berezin, Vladimir, Bock, Elisabeth, Walmod, Peter S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918577/
https://www.ncbi.nlm.nih.gov/pubmed/20663132
http://dx.doi.org/10.1186/1471-2407-10-383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918577/
https://www.ncbi.nlm.nih.gov/pubmed/20663132
http://dx.doi.org/10.1186/1471-2407-10-383

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