Immunization with Cocktail of HIV-Derived Peptides in Montanide ISA-51 Is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity

BACKGROUND: A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete Freund's adjuvant (IFA). METHODS: Low-risk, healthy adult sub...

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Detalles Bibliográficos
Autores principales: Graham, Barney S., McElrath, M. Juliana, Keefer, Michael C., Rybczyk, Kyle, Berger, David, Weinhold, Kent J., Ottinger, Janet, Ferarri, Guido, Montefiori, David C., Stablein, Don, Smith, Carol, Ginsberg, Richard, Eldridge, John, Duerr, Ann, Fast, Pat, Haynes, Barton F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919382/
https://www.ncbi.nlm.nih.gov/pubmed/20706632
http://dx.doi.org/10.1371/journal.pone.0011995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919382/
https://www.ncbi.nlm.nih.gov/pubmed/20706632
http://dx.doi.org/10.1371/journal.pone.0011995

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