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Ubc13 dosage is critical for immunoglobulin gene conversion and gene targeting in vertebrate cells
In contrast to lower eukaryotes, most vertebrate cells are characterized by a moderate efficiency of homologous recombination (HR) and limited feasibility of targeted genetic modifications. As a notable exception, the chicken DT40 B cell line is distinguished by efficient homology-mediated repair of...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919702/ https://www.ncbi.nlm.nih.gov/pubmed/20223767 http://dx.doi.org/10.1093/nar/gkq154 |