The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing

The use of short interfering RNAs (siRNA) in animals for target validation or as potential therapeutics is hindered by the short physical half-life when delivered as unencapsulated material and in turn the short active half-life of siRNAs in vivo. Here we demonstrate that the character of the two 3′...

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Detalles Bibliográficos
Autores principales: Strapps, Walter R., Pickering, Victoria, Muiru, Gladys T., Rice, Julie, Orsborn, Stacey, Polisky, Barry A., Sachs, Alan, Bartz, Steven R.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919711/
https://www.ncbi.nlm.nih.gov/pubmed/20360048
http://dx.doi.org/10.1093/nar/gkq206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919711/
https://www.ncbi.nlm.nih.gov/pubmed/20360048
http://dx.doi.org/10.1093/nar/gkq206

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