Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation

Orphan nuclear receptor Small Heterodimer Partner (SHP; NR0B2) is a transcriptional corepressor of a wide variety of nuclear receptors (NRs). Here, we report that SHP recruits SIRT1, a class III histone deacetylase, in an NR-specific manner to inhibit transcriptional activity. SHP interacts and co-l...

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Detalles Bibliográficos
Autores principales: Chanda, Dipanjan, Xie, Yuan-Bin, Choi, Hueng-Sik
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919721/
https://www.ncbi.nlm.nih.gov/pubmed/20375098
http://dx.doi.org/10.1093/nar/gkq227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919721/
https://www.ncbi.nlm.nih.gov/pubmed/20375098
http://dx.doi.org/10.1093/nar/gkq227

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