Identification of thymidylate synthase as a potential therapeutic target for lung cancer

BACKGROUND: Thymidylate synthase (TS), a key enzyme in the de novo synthesis of thymidine, is an important chemotherapeutic target for malignant tumours including lung cancer. Although inhibition of TS has an antiproliferative effect in cancer cells, the precise mechanism of this effect has remained...

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Detalles Bibliográficos
Autores principales: Takezawa, K, Okamoto, I, Tsukioka, S, Uchida, J, Kiniwa, M, Fukuoka, M, Nakagawa, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920030/
https://www.ncbi.nlm.nih.gov/pubmed/20628382
http://dx.doi.org/10.1038/sj.bjc.6605793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920030/
https://www.ncbi.nlm.nih.gov/pubmed/20628382
http://dx.doi.org/10.1038/sj.bjc.6605793

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