Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

GW182-family proteins are essential for microRNA-mediated translational repression and deadenylation in animal cells. Here we show that a conserved motif in the human GW182 paralog TNRC6C interacts with the C-terminal domain of polyadenylate binding protein 1 (PABC) and present the crystal structure...

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Detalles Bibliográficos
Autores principales: Jinek, Martin, Fabian, Marc R., Coyle, Scott M., Sonenberg, Nahum, Doudna, Jennifer A.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920127/
https://www.ncbi.nlm.nih.gov/pubmed/20098421
http://dx.doi.org/10.1038/nsmb.1768

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920127/
https://www.ncbi.nlm.nih.gov/pubmed/20098421
http://dx.doi.org/10.1038/nsmb.1768

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