Structure of Monoubiquitinated PCNA and Implications for Translesion Synthesis and DNA Polymerase Exchange

DNA synthesis by classical polymerases can be blocked by many lesions. These blocks are overcome by translesion synthesis, whereby the stalled classical, replicative polymerase is replaced by a non-classical polymerase. In eukaryotes, this polymerase exchange requires PCNA monoubiquitination. To bet...

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Detalles Bibliográficos
Autores principales: Freudenthal, Bret D., Gakhar, Lokesh, Ramaswamy, S., Washington, M. Todd
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920209/
https://www.ncbi.nlm.nih.gov/pubmed/20305653
http://dx.doi.org/10.1038/nsmb.1776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920209/
https://www.ncbi.nlm.nih.gov/pubmed/20305653
http://dx.doi.org/10.1038/nsmb.1776

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