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Structure of Monoubiquitinated PCNA and Implications for Translesion Synthesis and DNA Polymerase Exchange
DNA synthesis by classical polymerases can be blocked by many lesions. These blocks are overcome by translesion synthesis, whereby the stalled classical, replicative polymerase is replaced by a non-classical polymerase. In eukaryotes, this polymerase exchange requires PCNA monoubiquitination. To bet...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920209/ https://www.ncbi.nlm.nih.gov/pubmed/20305653 http://dx.doi.org/10.1038/nsmb.1776 |