Cargando…

α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra

The protein α-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic strategies aimed at reducing neuronal α-synuclein bu...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCormack, Alison L., Mak, Sally K., Henderson, Jaimie M., Bumcrot, David, Farrer, Matthew J., Di Monte, Donato A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920329/ https://www.ncbi.nlm.nih.gov/pubmed/20711464 http://dx.doi.org/10.1371/journal.pone.0012122

Ejemplares similares

Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra
por: McCormack, A L, et al.
Publicado: (2012)

Blood-Derived α-Synuclein Aggregated in the Substantia Nigra of Parabiotic Mice
por: Ma, Xizhen, et al.
Publicado: (2021)

Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats
por: Yu, Zhongwang, et al.
Publicado: (2010)

Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
por: Croisier, Emilie, et al.
Publicado: (2005)

Soemmerring and the Substantia Nigra
por: Faull, R. L. M, et al.
Publicado: (1968)

Correction: Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
por: Croisier, Emilie, et al.
Publicado: (2006)

α-Synuclein Expression Is Preserved in Substantia Nigra GABAergic Fibers of Young and Aged Neurotoxin-Treated Rhesus Monkeys
por: Vermilyea, Scott C., et al.
Publicado: (2019)

Nano-imaging trace elements at organelle levels in substantia nigra overexpressing α-synuclein to model Parkinson’s disease
por: Lemelle, Laurence, et al.
Publicado: (2020)

Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis
por: Guo, Jian-Jun, et al.
Publicado: (2021)

A dual role for α-synuclein in facilitation and depression of dopamine release from substantia nigra neurons in vivo
por: Somayaji, Mahalakshmi, et al.
Publicado: (2020)

Synuclein Proteins in MPTP-Induced Death of Substantia Nigra Pars Compacta Dopaminergic Neurons
por: Goloborshcheva, Valeria V., et al.
Publicado: (2022)

Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease
por: Flønes, Irene Hana, et al.
Publicado: (2022)

Neuronal haemoglobin induces loss of dopaminergic neurons in mouse Substantia nigra, cognitive deficits and cleavage of endogenous α-synuclein
por: Santulli, Chiara, et al.
Publicado: (2022)

Analysis of α-synuclein levels related to LRRK2 kinase activity: from substantia nigra to urine of patients with Parkinson’s disease
por: Nam, Daleum, et al.
Publicado: (2021)

α-Synuclein Aggregates Increase the Conductance of Substantia Nigra Dopamine Neurons, an Effect Partly Reversed by the KATP Channel Inhibitor Glibenclamide
por: Hill, E., et al.
Publicado: (2021)

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease
por: Gründemann, Jan, et al.
Publicado: (2008)

The history of the research of iron in parkinsonian substantia nigra
por: Friedman, Andrzej, et al.
Publicado: (2012)

Isolated substantia nigra involvement in brainstem demyelination
por: Mahale, Rohan R., et al.
Publicado: (2015)

Nicotine impact on rat substantia nigra compacta
por: Elgayar, Sanaa A M, et al.
Publicado: (2021)

Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra
por: Salado-Castillo, Rigoberto, et al.
Publicado: (2011)

Proteome analysis of human substantia nigra in Parkinson's disease
por: Werner, Cornelius J, et al.
Publicado: (2008)

Bidirectional Modulation of Substantia Nigra Activity by Motivational State
por: Rossi, Mark A., et al.
Publicado: (2013)

Operant Self-Stimulation of Dopamine Neurons in the Substantia Nigra
por: Rossi, Mark A., et al.
Publicado: (2013)

Epstein-Barr virus encephalitis with substantia nigra involvement
por: Çelik, Tamer, et al.
Publicado: (2015)

Mesencephalic origin of the rostral Substantia nigra pars reticulata
por: Madrigal, M. Pilar, et al.
Publicado: (2015)

Glucocerebrosidase Deficiency in Substantia Nigra of Parkinson Disease Brains
por: Gegg, Matthew E, et al.
Publicado: (2012)

Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction
por: Ohtomo, Gaku, et al.
Publicado: (2017)

Proliferation of Inhibitory Input to the Substantia Nigra in Experimental Parkinsonism
por: Faynveitz, Anna, et al.
Publicado: (2019)

Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brain
por: Tarasova, Tatiana V., et al.
Publicado: (2018)

Complement activation in the Parkinson's disease substantia nigra: an immunocytochemical study
por: Loeffler, David A, et al.
Publicado: (2006)

Parcellation of the human substantia nigra based on anatomical connectivity to the striatum()
por: Chowdhury, Rumana, et al.
Publicado: (2013)

Tollip, an early regulator of the acute inflammatory response in the substantia nigra
por: Humbert-Claude, Marie, et al.
Publicado: (2016)

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease
por: Dölle, Christian, et al.
Publicado: (2016)

Age-Mediated Transcriptomic Changes in Adult Mouse Substantia Nigra
por: Gao, Lin, et al.
Publicado: (2013)

Sex-Related Abnormalities in Substantia Nigra Lipids in Parkinson’s Disease
por: Seyfried, T. N., et al.
Publicado: (2018)

Genetic and constitutional factors are major contributors to substantia nigra hyperechogenicity
por: Vázquez-Costa, Juan F., et al.
Publicado: (2017)

Anatomical and functional organization of the human substantia nigra and its connections
por: Zhang, Yu, et al.
Publicado: (2017)

Regional microglial activation in the substantia nigra is linked with fatigue in MS
por: Singhal, Tarun, et al.
Publicado: (2020)

The effect of titanium dioxide nanoparticles on mice midbrain substantia nigra
por: Heidari, Zahra, et al.
Publicado: (2019)

Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
por: Trist, Benjamin G., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6n60rk0fj8c7vg1vv81s1g01fa