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Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress
The p63 gene product regulates epithelial morphogenesis and female germline integrity. In this study, we show that cyclin-dependent kinase 5 and Abl enzyme substrate 1 (Cables1) interacts with the trans-activating (TA) p63α isoform to protect it from proteasomal degradation. Using the female germlin...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920443/ https://www.ncbi.nlm.nih.gov/pubmed/20559324 http://dx.doi.org/10.1038/embor.2010.82 |