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Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters
Ion binding to secondary active transporters triggers a cascade of conformational rearrangements resulting in substrate translocation across cellular membranes. Despite the fundamental role of this step, direct measurements of binding to transporters are rare. We investigated ion binding and selecti...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920496/ https://www.ncbi.nlm.nih.gov/pubmed/19898476 http://dx.doi.org/10.1038/nsmb.1704 |