Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin

Signal transducer and activator of transcription-5 (STAT5) is a critical transcription factor for normal hematopoiesis and its sustained activation is associated with hematologic malignancy. A persistently active mutant of STAT5 (STAT5a(S711F)) associates with Grb2 associated binding protein 2 (Gab2...

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Detalles Bibliográficos
Autores principales: Li, Geqiang, Miskimen, Kristy L., Wang, Zhengqi, Xie, Xiu Yan, Tse, William, Gouilleux, Fabrice, Moriggl, Richard, Bunting, Kevin D.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921023/
https://www.ncbi.nlm.nih.gov/pubmed/20535152
http://dx.doi.org/10.1038/leu.2010.131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921023/
https://www.ncbi.nlm.nih.gov/pubmed/20535152
http://dx.doi.org/10.1038/leu.2010.131

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