Phosphatidic Acid Induces Ligand-independent Epidermal Growth Factor Receptor Endocytic Traffic through PDE4 Activation

Endocytosis modulates EGFR function by compartmentalizing and attenuating or enhancing its ligand-induced signaling. Here we show that it can also control the cell surface versus intracellular distribution of empty/inactive EGFR. Our previous observation that PKA inhibitors induce EGFR internalizati...

Descripción completa

Detalles Bibliográficos
Autores principales: Norambuena, Andrés, Metz, Claudia, Jung, Juan E., Silva, Antonia, Otero, Carolina, Cancino, Jorge, Retamal, Claudio, Valenzuela, Juan C., Soza, Andrea, González, Alfonso
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921116/
https://www.ncbi.nlm.nih.gov/pubmed/20554760
http://dx.doi.org/10.1091/mbc.E10-02-0167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921116/
https://www.ncbi.nlm.nih.gov/pubmed/20554760
http://dx.doi.org/10.1091/mbc.E10-02-0167

Ejemplares similares