Ago-TNRC6 complex triggers microRNA-mediated mRNA decay by promoting biphasic deadenylation followed by decapping

MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly through promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear. Combining the approaches of transcriptional pulsing, RNA-tethering, over-expressi...

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Detalles Bibliográficos
Autores principales: Chen, Chyi-Ying A., Zheng, Dinghai, Xia, Zhenfang, Shyu, Ann-Bin
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921184/
https://www.ncbi.nlm.nih.gov/pubmed/19838187
http://dx.doi.org/10.1038/nsmb.1709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2921184/
https://www.ncbi.nlm.nih.gov/pubmed/19838187
http://dx.doi.org/10.1038/nsmb.1709

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