Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils

The Aβ42 peptide rapidly aggregates to form oligomers, protofibils and fibrils en route to the deposition of amyloid plaques associated with Alzheimer's disease. We show that low temperature and low salt can stabilize disc-shaped oligomers (pentamers) that are significantly more toxic to murine...

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Detalles Bibliográficos
Autores principales: Ahmed, Mahiuddin, Davis, Judianne, Aucoin, Darryl, Sato, Takeshi, Ahuja, Shivani, Aimoto, Saburo, Elliott, James I., Van Nostrand, William E., Smith, Steven O.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922021/
https://www.ncbi.nlm.nih.gov/pubmed/20383142
http://dx.doi.org/10.1038/nsmb.1799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922021/
https://www.ncbi.nlm.nih.gov/pubmed/20383142
http://dx.doi.org/10.1038/nsmb.1799

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