Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2

Using chemical genetics to reversibly inhibit Cdk1, we find that cells arrested in late G2 are unable to delay mitotic entry after irradiation. Late G2 cells detect DNA damage lesions and form γ-H2AX foci but fail to activate Chk1. This reflects a lack of DNA double-strand break processing because l...

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Detalles Bibliográficos
Autores principales: Xu, Naihan, Hegarat, Nadia, Black, Elizabeth J., Scott, Mary T., Hochegger, Helfrid, Gillespie, David A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922641/
https://www.ncbi.nlm.nih.gov/pubmed/20679434
http://dx.doi.org/10.1083/jcb.201003004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922641/
https://www.ncbi.nlm.nih.gov/pubmed/20679434
http://dx.doi.org/10.1083/jcb.201003004

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