Single-molecule FRET-derived model of the synaptotagmin 1–SNARE fusion complex

Synchronous neurotransmission is triggered when Ca(2+) binds to synaptotagmin 1, a synaptic vesicle protein that interacts with SNAREs and membranes. We used single-molecule FRET between synaptotagmin’s two C2 domains to determine that their conformation consists of multiple states with occasional t...

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Detalles Bibliográficos
Autores principales: Choi, Ucheor B., Strop, Pavel, Vrljic, Marija, Chu, Steven, Brunger, Axel T., Weninger, Keith R.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922927/
https://www.ncbi.nlm.nih.gov/pubmed/20173763
http://dx.doi.org/10.1038/nsmb.1763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922927/
https://www.ncbi.nlm.nih.gov/pubmed/20173763
http://dx.doi.org/10.1038/nsmb.1763

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