Combinatorial profiling of chromatin-binding modules reveals multi-site discrimination

Specific interactions between post-translational modifications (PTMs) and chromatin-binding proteins are central to the idea of a ‘histone code’. Here, a 5000-member, PTM-randomized, combinatorial peptide library based on the N-terminus of histone H3 was utilized to interrogate multi-site specificit...

Descripción completa

Detalles Bibliográficos
Autores principales: Garske, Adam L., Oliver, Samuel S., Wagner, Elise K., Musselman, Catherine A., LeRoy, Gary, Garcia, Benjamin A., Kutateladze, Tatiana G., Denu, John M.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922993/
https://www.ncbi.nlm.nih.gov/pubmed/20190764
http://dx.doi.org/10.1038/nchembio.319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922993/
https://www.ncbi.nlm.nih.gov/pubmed/20190764
http://dx.doi.org/10.1038/nchembio.319

Ejemplares similares