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The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice via activation of Wnt and ERK1/2 MAPK pathways
Somatically acquired, activating mutations of GNAS, the gene encoding the stimulatory G-protein Gsα subunit, have been identified in kidney, thyroid, pituitary, leydig cell, adrenocortical and more recently, in colorectal tumours, suggesting that mutations such as R201C may be oncogenic in these tis...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923080/ https://www.ncbi.nlm.nih.gov/pubmed/20531296 http://dx.doi.org/10.1038/onc.2010.202 |