MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing

During gametogenesis and pre-implantation development, the mammalian epigenome is reprogrammed to establish pluripotency in the epiblast. Here we show that the histone 3 lysine 4 (H3K4) methyltransferase, MLL2, controls most of the promoter-specific chromatin modification, H3K4me3, during oogenesis...

Descripción completa

Detalles Bibliográficos
Autores principales: Andreu-Vieyra, Claudia V., Chen, Ruihong, Agno, Julio E., Glaser, Stefan, Anastassiadis, Konstantinos, Stewart, A. Francis, Matzuk, Martin M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923083/
https://www.ncbi.nlm.nih.gov/pubmed/20808952
http://dx.doi.org/10.1371/journal.pbio.1000453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923083/
https://www.ncbi.nlm.nih.gov/pubmed/20808952
http://dx.doi.org/10.1371/journal.pbio.1000453

Ejemplares similares