A Transposon in Comt Generates mRNA Variants and Causes Widespread Expression and Behavioral Differences among Mice

BACKGROUND: Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine. COMT activity influences cognitive and emotional states in humans and aggression and drug responses in mice. This study identifies the key sequence variant that leads to di...

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Detalles Bibliográficos
Autores principales: Li, Zhengsheng, Mulligan, Megan K., Wang, Xusheng, Miles, Michael F., Lu, Lu, Williams, Robert W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923157/
https://www.ncbi.nlm.nih.gov/pubmed/20808911
http://dx.doi.org/10.1371/journal.pone.0012181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923157/
https://www.ncbi.nlm.nih.gov/pubmed/20808911
http://dx.doi.org/10.1371/journal.pone.0012181

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