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A Transposon in Comt Generates mRNA Variants and Causes Widespread Expression and Behavioral Differences among Mice
BACKGROUND: Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine. COMT activity influences cognitive and emotional states in humans and aggression and drug responses in mice. This study identifies the key sequence variant that leads to di...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923157/ https://www.ncbi.nlm.nih.gov/pubmed/20808911 http://dx.doi.org/10.1371/journal.pone.0012181 |