Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways: ROLE OF A PHOSPHOLIPASE A(2)(cPLA(2))/CYCLOOXYGENASE-2 (COX-2)/PROSTACYCLIN RECEPTOR-DEPENDENT AUTOCRINE LOOP

Several important genes that are involved in inflammation and tissue remodeling are switched on by virtue of CRE response elements in their promoters. The upstream signaling mechanisms that inflammatory mediators use to activate cAMP response elements (CREs) are poorly understood. Endothelin (ET) is...

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Detalles Bibliográficos
Autores principales: Deacon, Karl, Knox, Alan J.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923981/
https://www.ncbi.nlm.nih.gov/pubmed/20452970
http://dx.doi.org/10.1074/jbc.M110.139485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923981/
https://www.ncbi.nlm.nih.gov/pubmed/20452970
http://dx.doi.org/10.1074/jbc.M110.139485

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