Cargando…

Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways: ROLE OF A PHOSPHOLIPASE A(2)(cPLA(2))/CYCLOOXYGENASE-2 (COX-2)/PROSTACYCLIN RECEPTOR-DEPENDENT AUTOCRINE LOOP

Several important genes that are involved in inflammation and tissue remodeling are switched on by virtue of CRE response elements in their promoters. The upstream signaling mechanisms that inflammatory mediators use to activate cAMP response elements (CREs) are poorly understood. Endothelin (ET) is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deacon, Karl, Knox, Alan J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2010
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923981/ https://www.ncbi.nlm.nih.gov/pubmed/20452970 http://dx.doi.org/10.1074/jbc.M110.139485

Ejemplares similares

Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A
por: Sieng, Monita, et al.
Publicado: (2021)

Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in β Cells
por: Wuttke, Anne, et al.
Publicado: (2016)

AKAP79/150 Interacts with AC8 and Regulates Ca(2+)-dependent cAMP Synthesis in Pancreatic and Neuronal Systems
por: Willoughby, Debbie, et al.
Publicado: (2010)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca(2+) Release
por: Cook, Zara C., et al.
Publicado: (2012)

Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth
por: Klöting, Nora, et al.
Publicado: (2008)

Rac Regulates Its Effector Phospholipase Cγ(2) through Interaction with a Split Pleckstrin Homology Domain
por: Walliser, Claudia, et al.
Publicado: (2008)

CC2D1A, a DM14 and C2 Domain Protein, Activates NF-κB through the Canonical Pathway
por: Zhao, Meng, et al.
Publicado: (2010)

Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells
por: Pollitt, Alice Y., et al.
Publicado: (2014)

Submaximal Inhibition of Protein Kinase C Restores ADP-induced Dense Granule Secretion in Platelets in the Presence of Ca(2+)
por: Unsworth, Amanda J., et al.
Publicado: (2011)

IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold
por: Dixon, Miles J., et al.
Publicado: (2012)

Inhibition of Cardiomyocytes Differentiation of Mouse Embryonic Stem Cells by CD38/cADPR/Ca(2+) Signaling Pathway
por: Wei, Wen-Jie, et al.
Publicado: (2012)

Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS
por: Thompson, Dawn, et al.
Publicado: (2014)

Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)
por: Hughes, Craig E., et al.
Publicado: (2013)

Protein Kinase Cθ Negatively Regulates Store-independent Ca(2+) Entry and Phosphatidylserine Exposure Downstream of Glycoprotein VI in Platelets
por: Harper, Matthew T., et al.
Publicado: (2010)

Class II Histone Deacetylases Downregulate GLUT4 Transcription in Response to Increased cAMP Signaling in Cultured Adipocytes and Fasting Mice
por: Weems, Juston C., et al.
Publicado: (2012)

Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A(2) (GIVA cPLA(2))
por: Psarra, Anastasia, et al.
Publicado: (2018)

Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes
por: Christian, Frank, et al.
Publicado: (2011)

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2)
por: Weston, Cathryn, et al.
Publicado: (2015)

4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass
por: Blandino-Rosano, Manuel, et al.
Publicado: (2016)

Selective Orthosteric Free Fatty Acid Receptor 2 (FFA2) Agonists: IDENTIFICATION OF THE STRUCTURAL AND CHEMICAL REQUIREMENTS FOR SELECTIVE ACTIVATION OF FFA2 VERSUS FFA3
por: Schmidt, Johannes, et al.
Publicado: (2011)

Ca(2+) Signals Generated by CatSper and Ca(2+) Stores Regulate Different Behaviors in Human Sperm
por: Alasmari, Wardah, et al.
Publicado: (2013)

Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH
por: Lu, Yingying, et al.
Publicado: (2013)

Lobe-specific Functions of Ca(2+)·Calmodulin in αCa(2+)·Calmodulin-dependent Protein Kinase II Activation
por: Jama, Abdirahman M., et al.
Publicado: (2011)

Correction to “Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A(2) (GIVA cPLA(2))”
por: Psarra, Anastasia, et al.
Publicado: (2019)

Increase in Serum Ca(2+/)Mg(2+) Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels
por: Sun, Yuyang, et al.
Publicado: (2013)

Expression of Cytosolic Phospholipase A2 (cPLA2)-Arachidonic Acid (AA)-Cyclooxygenase-2 (COX-2) Pathway Factors in Lung Cancer Patients and Its Implication in Lung Cancer Early Detection and Prognosis
por: Xin, Chunxia, et al.
Publicado: (2019)

Caveolin-1 Alters the Pattern of Cytoplasmic Ca(2+) Oscillations and Ca(2+)-dependent Gene Expression by Enhancing Leukotriene Receptor Desensitization
por: Yeh, Yi-Chun, et al.
Publicado: (2014)

Molecularly Distinct Routes of Mitochondrial Ca(2+) Uptake Are Activated Depending on the Activity of the Sarco/Endoplasmic Reticulum Ca(2+) ATPase (SERCA)
por: Waldeck-Weiermair, Markus, et al.
Publicado: (2013)

Parkin Regulates the Activity of Pyruvate Kinase M2
por: Liu, Kun, et al.
Publicado: (2016)

Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
por: Soares, Marc A., et al.
Publicado: (2016)

Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2
por: Saito, Atsushi, et al.
Publicado: (2011)

Engagement of Nucleotide-binding Oligomerization Domain-containing Protein 1 (NOD1) by Receptor-interacting Protein 2 (RIP2) Is Insufficient for Signal Transduction
por: Mayle, Sophie, et al.
Publicado: (2014)

Insulin Growth Factor-2 Binding Protein 3 (IGF2BP3) Is a Glioblastoma-specific Marker That Activates Phosphatidylinositol 3-Kinase/Mitogen-activated Protein Kinase (PI3K/MAPK) Pathways by Modulating IGF-2
por: Suvasini, Ramaswamy, et al.
Publicado: (2011)

Local Cytosolic Ca(2+) Elevations Are Required for Stromal Interaction Molecule 1 (STIM1) De-oligomerization and Termination of Store-operated Ca(2+) Entry
por: Shen, Wei-Wei, et al.
Publicado: (2011)

Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice
por: Uchida, Kunitoshi, et al.
Publicado: (2011)

Communication between N terminus and loop2 tunes Orai activation
por: Fahrner, Marc, et al.
Publicado: (2018)

G Protein–Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta
por: Taguchi, Kumiko, et al.
Publicado: (2012)

Recruitment of a Cytoplasmic Chaperone Relay by the A(2A) Adenosine Receptor
por: Bergmayr, Christian, et al.
Publicado: (2013)

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
por: Gilio, Karen, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_vd41rijrgkvkd8es5f1q07blcd