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Enhancing cytotoxic and apoptotic effect in OVCAR-3 and MDAH-2774 cells with all-trans retinoic acid and zoledronic acid: a paradigm of synergistic molecular targeting treatment for ovarian cancer

BACKGROUND: Ovarian cancer is the most fatal gynecologic malignancies in the world. Although, platinum based treatments are widely used, the disease becomes treatment refractory within two years, and novel treatment options should be searched. All- trans retinoic acid (ATRA) induces growth arrest, d...

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Detalles Bibliográficos
Autores principales: Karabulut, Bulent, Karaca, Burcak, Varol, Umut, Muslu, Ugur, Cakar, Burcu, Atmaca, Harika, Kısım, Aslı, Uzunoglu, Selim, Uslu, Ruchan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924277/
https://www.ncbi.nlm.nih.gov/pubmed/20673323
http://dx.doi.org/10.1186/1756-9966-29-102