Cargando…

Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells

BACKGROUND: The presence of the cellular Lens Epithelium Derived Growth Factor p75 (LEDGF/p75) protein is essential for integration of the Human immunodeficiency virus type 1 (HIV-1) cDNA and for efficient virus production. In the absence of LEDGF/p75 very little integration and virus production can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Levin, Aviad, Hayouka, Zvi, Friedler, Assaf, Loyter, Abraham
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924314/ https://www.ncbi.nlm.nih.gov/pubmed/20678206 http://dx.doi.org/10.1186/1743-422X-7-177

Ejemplares similares

Peptides Derived from HIV-1 Integrase that Bind Rev Stimulate Viral Genome Integration
por: Levin, Aviad, et al.
Publicado: (2009)

Specific eradication of HIV-1 from infected cultured cells
por: Levin, Aviad, et al.
Publicado: (2010)

The Lentiviral Integrase Binding Protein LEDGF/p75 and HIV-1 Replication
por: Engelman, Alan, et al.
Publicado: (2008)

The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75
por: Zhang, Da-Wei, et al.
Publicado: (2020)

HIV-1 integrase modulates the interaction of the HIV-1 cellular cofactor LEDGF/p75 with chromatin
por: Astiazaran, Paulina, et al.
Publicado: (2011)

Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal
por: Levin, Aviad, et al.
Publicado: (2009)

Modulation of the intrinsic chromatin binding property of HIV-1 integrase by LEDGF/p75
por: Lapaillerie, Delphine, et al.
Publicado: (2021)

LEDGF/p75 Deficiency Increases Deletions at the HIV-1 cDNA Ends
por: Bueno, Murilo T. D., et al.
Publicado: (2017)

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
por: Desimmie, Belete Ayele, et al.
Publicado: (2015)

Characterization of the HIV-1 integrase chromatin- and LEDGF/p75-binding abilities by mutagenic analysis within the catalytic core domain of integrase
por: Zheng, Yingfeng, et al.
Publicado: (2010)

Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles
por: Desimmie, Belete Ayele, et al.
Publicado: (2020)

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV
por: Vranckx, Lenard S., et al.
Publicado: (2016)

Molecular Modeling Study on the Allosteric Inhibition Mechanism of HIV-1 Integrase by LEDGF/p75 Binding Site Inhibitors
por: Xue, Weiwei, et al.
Publicado: (2014)

Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses
por: Wang, Hao, et al.
Publicado: (2014)

Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors
por: Singh, Parmit Kumar, et al.
Publicado: (2022)

A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site
por: Maehigashi, Tatsuya, et al.
Publicado: (2021)

HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor
por: Wang, Hao, et al.
Publicado: (2012)

An Unusual Helix Turn Helix Motif in the Catalytic Core of HIV-1 Integrase Binds Viral DNA and LEDGF
por: Merad, Hayate, et al.
Publicado: (2009)

Evaluation of a flavonoid library for inhibition of interaction of HIV-1 integrase with human LEDGF/p75 towards a structure–activity relationship
por: Yin, Zhi-Hui, et al.
Publicado: (2022)

LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
por: Cherepanov, Peter
Publicado: (2007)

LEDGF/p75 is critical but not essential for multiple-round HIV 1 replication
por: Schrijvers, RLG, et al.
Publicado: (2010)

Studies on HIV integrase-LEDGF/p75 interaction inhibitory activity of isatine derivative using the alpha screen luminescent proximity assay
por: Selvam, Periyasamy
Publicado: (2012)

Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage
por: Le Rouzic, Erwann, et al.
Publicado: (2013)

LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors
por: Meehan, Anne M., et al.
Publicado: (2009)

Characterization of LEDGF/p75 Genetic Variants and Association with HIV-1 Disease Progression
por: Messiaen, Peter, et al.
Publicado: (2012)

Intracellular immunization against HIV infection with an intracellular antibody that mimics HIV integrase binding to the cellular LEDGF protein
por: Bao, Leyuan, et al.
Publicado: (2017)

Dihydroxyphenyl- and Heteroaromatic-Based Thienopyrimidinones to Tackle HIV-1 LEDGF/p75-Dependent IN Activity
por: Tocco, Graziella, et al.
Publicado: (2023)

A Novel Assay for Screening Inhibitors Targeting HIV Integrase LEDGF/p75 Interaction Based on Ni(2+) Coated Magnetic Agarose Beads
por: Dawei, Zhang, et al.
Publicado: (2016)

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells
por: Schrijvers, Rik, et al.
Publicado: (2012)

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes
por: Singh, Parmit Kumar, et al.
Publicado: (2015)

Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV
por: Hombrouck, Anneleen, et al.
Publicado: (2007)

Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro
por: Botbol, Yaïr, et al.
Publicado: (2008)

LEDGF/p75 controls 3D-localization of HIV-1 provirus in the nuclear compartment of infected cells
por: Boll, Annegret, et al.
Publicado: (2013)

Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection
por: Lampi, Yulia, et al.
Publicado: (2019)

HIV-1 integrase SUMOylation and viral replication
por: Zamborlini, Alessia, et al.
Publicado: (2011)

The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights
por: Hare, Stephen, et al.
Publicado: (2009)

Analysis of LEDGF/p75 expression regulation
por: Desfarges, Sébastien, et al.
Publicado: (2009)

A Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75
por: Hare, Stephen, et al.
Publicado: (2009)

Association of Single Nucleotide Polymorphisms in the Lens Epithelium-Derived Growth Factor (LEDGF/p75) with HIV-1 Infection Outcomes in Brazilian HIV-1+ Individuals
por: Passaes, Caroline Pereira Bittencourt, et al.
Publicado: (2014)

The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells
por: Ortiz-Hernandez, Greisha L., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_c5e5q7fkn76enoc55qsqj4qkco