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Functional Characterisation and Drug Target Validation of a Mitotic Kinesin-13 in Trypanosoma brucei
Mitotic kinesins are essential for faithful chromosome segregation and cell proliferation. Therefore, in humans, kinesin motor proteins have been identified as anti-cancer drug targets and small molecule inhibitors are now tested in clinical studies. Phylogenetic analyses have assigned five of the a...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924347/ https://www.ncbi.nlm.nih.gov/pubmed/20808899 http://dx.doi.org/10.1371/journal.ppat.1001050 |