Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex

Biochemical studies suggest that G-protein-coupled receptors (GPCRs) achieve exquisite signalling specificity by forming selective complexes, termed signalosomes. Here, using cAMP biosensors in single cells, we uncover a pre-assembled, constitutively active GPCR signalosome, that couples the relaxin...

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Detalles Bibliográficos
Autores principales: Halls, Michelle L, Cooper, Dermot M F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924647/
https://www.ncbi.nlm.nih.gov/pubmed/20664520
http://dx.doi.org/10.1038/emboj.2010.168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924647/
https://www.ncbi.nlm.nih.gov/pubmed/20664520
http://dx.doi.org/10.1038/emboj.2010.168

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