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PKCα-induced drug resistance in pancreatic cancer cells is associated with transforming growth factor-β1

BACKGROUND: Drug resistance remains a great challenge in the treatment of pancreatic cancer. The goal of this study was to determine whether TGF-β1 is associated with drug resistance in pancreatic cancer. METHODS: Pancreatic cancer BxPC3 cells were stably transfected with TGF-β1 cDNA. Cellular morph...

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Detalles Bibliográficos
Autores principales: Chen, Ying, Yu, Guanzhen, Yu, Danghui, Zhu, Minghua
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924847/
https://www.ncbi.nlm.nih.gov/pubmed/20684793
http://dx.doi.org/10.1186/1756-9966-29-104