Expression of Human Frataxin Is Regulated by Transcription Factors SRF and TFAP2

BACKGROUND: Friedreich ataxia is an autosomal recessive neurodegenerative disease caused by reduced expression levels of the frataxin gene (FXN) due to expansion of triplet nucleotide GAA repeats in the first intron of FXN. Augmentation of frataxin expression levels in affected Friedreich ataxia pat...

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Detalles Bibliográficos
Autores principales: Li, Kuanyu, Singh, Anamika, Crooks, Daniel R., Dai, Xiaoman, Cong, Zhuangzhuang, Pan, Liang, Ha, Dung, Rouault, Tracey A.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924884/
https://www.ncbi.nlm.nih.gov/pubmed/20808827
http://dx.doi.org/10.1371/journal.pone.0012286

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924884/
https://www.ncbi.nlm.nih.gov/pubmed/20808827
http://dx.doi.org/10.1371/journal.pone.0012286

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