Differential Toxicity of DNA Adducts of Mitomycin C

The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. This review focuses on differential biological effects of individual adducts in various mammalian cell cultures, observed in the authors' laboratories....

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Detalles Bibliográficos
Autores principales: Bargonetti, Jill, Champeil, Elise, Tomasz, Maria
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925095/
https://www.ncbi.nlm.nih.gov/pubmed/20798760
http://dx.doi.org/10.4061/2010/698960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925095/
https://www.ncbi.nlm.nih.gov/pubmed/20798760
http://dx.doi.org/10.4061/2010/698960

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