A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics

BACKGROUND: Farnesyltransferase inhibitors (FTIs) are anticancer agents developed to inhibit Ras oncoprotein activities. FTIs of different chemical structure act via a conserved mechanism in eukaryotic cells. They have low toxicity and are active on a wide range of tumors in cellular and animal mode...

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Detalles Bibliográficos
Autores principales: Porcu, Giampiero, Wilson, Cathal, Di Giandomenico, Daniele, Ragnini-Wilson, Antonella
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925370/
https://www.ncbi.nlm.nih.gov/pubmed/20653956
http://dx.doi.org/10.1186/1476-4598-9-197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925370/
https://www.ncbi.nlm.nih.gov/pubmed/20653956
http://dx.doi.org/10.1186/1476-4598-9-197

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