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A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics
BACKGROUND: Farnesyltransferase inhibitors (FTIs) are anticancer agents developed to inhibit Ras oncoprotein activities. FTIs of different chemical structure act via a conserved mechanism in eukaryotic cells. They have low toxicity and are active on a wide range of tumors in cellular and animal mode...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925370/ https://www.ncbi.nlm.nih.gov/pubmed/20653956 http://dx.doi.org/10.1186/1476-4598-9-197 |