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Metformin Improves Insulin Signaling in Obese Rats via Reduced IKKβ Action in a Fiber-Type Specific Manner
Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) in this same tissue are unknown. The aim of this study was to (1) determine th...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925476/ https://www.ncbi.nlm.nih.gov/pubmed/20798864 http://dx.doi.org/10.1155/2010/970865 |