Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice

Levels of glutathione are lower in the substantia nigra (SN) early in Parkinson's disease (PD) and this may contribute to mitochondrial dysfunction and oxidative stress. Oxidative stress may increase the accumulation of toxic forms of α-synuclein (SNCA). We hypothesized that supplementation wit...

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Detalles Bibliográficos
Autores principales: Clark, Joanne, Clore, Elizabeth L., Zheng, Kangni, Adame, Anthony, Masliah, Eliezer, Simon, David K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925900/
https://www.ncbi.nlm.nih.gov/pubmed/20808797
http://dx.doi.org/10.1371/journal.pone.0012333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925900/
https://www.ncbi.nlm.nih.gov/pubmed/20808797
http://dx.doi.org/10.1371/journal.pone.0012333

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