The Mechanism of Release of P-TEFb and HEXIM1 from the 7SK snRNP by Viral and Cellular Activators Includes a Conformational Change in 7SK

BACKGROUND: The positive transcription elongation factor, P-TEFb, is required for the production of mRNAs, however the majority of the factor is present in the 7SK snRNP where it is inactivated by HEXIM1. Expression of HIV-1 Tat leads to release of P-TEFb and HEXIM1 from the 7SK snRNP in vivo, but t...

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Detalles Bibliográficos
Autores principales: Krueger, Brian J., Varzavand, Katayoun, Cooper, Jeffrey J., Price, David H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925947/
https://www.ncbi.nlm.nih.gov/pubmed/20808803
http://dx.doi.org/10.1371/journal.pone.0012335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925947/
https://www.ncbi.nlm.nih.gov/pubmed/20808803
http://dx.doi.org/10.1371/journal.pone.0012335

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