Glycosaminoglycan Sulphation Affects the Seeded Misfolding of a Mutant Prion Protein

BACKGROUND: The accumulation of protease resistant conformers of the prion protein (PrP(res)) is a key pathological feature of prion diseases. Polyanions, including RNA and glycosaminoglycans have been identified as factors that contribute to the propagation, transmission and pathogenesis of prion d...

Descripción completa

Detalles Bibliográficos
Autores principales: Lawson, Victoria A., Lumicisi, Brooke, Welton, Jeremy, Machalek, Dorothy, Gouramanis, Katrina, Klemm, Helen M., Stewart, James D., Masters, Colin L., Hoke, David E., Collins, Steven J., Hill, Andrew F.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925953/
https://www.ncbi.nlm.nih.gov/pubmed/20808809
http://dx.doi.org/10.1371/journal.pone.0012351

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925953/
https://www.ncbi.nlm.nih.gov/pubmed/20808809
http://dx.doi.org/10.1371/journal.pone.0012351

Ejemplares similares